Please attend appointments fasting.
You will be asked to attend for study visits fasting (no food and drinks for 8 hours overnight, water allowed).
Screening Visit
- Medical history and physical examination
- Food diary, activity monitors started
- Blood tests
- Pregnancy tests for women of child bearing potential
Visit 1
(Week 0)
- Update on progress, physical examination
- Food diaries are collected
- Quality of life questionnaire
- Blood, urine, stool samples
- Subjects are randomised to receive medication + dietary/exercise advice or dietary/exercise advice alone
- Medication is given (to those in the semaglutide group)
- Activity monitor data is uploaded
- Pregnancy tests for women of child bearing potential
- DXA scan (to assess body composition and bone density)
- Fibroscan (to assess liver stiffness)
- ECG (to assess heart function)
Visit 2
(Week 4)
- Update on progress, physical examination
- Blood samples
- Medication is given (to those in the semaglutide group)
- Pregnancy tests for women of child bearing potential
- ECG (to assess heart function)
Visit 3
(Week 8)
- Update on progress, physical examination
- Blood, urine samples
- Medication is given (to those in the semaglutide group)
- Pregnancy tests for women of child bearing potential
Visit 4
(Week 16)
- Update on progress, physical examination
- New food diaries started
- Blood, urine samples
- Medication is given (to those in the semaglutide group)
- Activity monitor data is uploaded
- Pregnancy tests for women of child bearing potential
Visit 5
(Week 28)
- Update on progress, physical examination
- Food diaries are collected
- Quality of life questionnaire
- Blood, urine, stool samples
- Activity monitors and all unused medication are collected
- Pregnancy tests for women of child bearing potential
- DXA scan (to assess body composition and bone density)
- Fibroscan (to assess liver stiffness)
Follow-up Visit
(Week 40)
- Update on progress, physical examination
- Blood, urine, stool samples