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Please attend appointments fasting.

You will be asked to attend for study visits fasting (no food and drinks for 8 hours overnight, water allowed).

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Screening Visit 

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  • Medical history and physical examination
  • Food diary, activity monitors started
  • Blood tests
  • Pregnancy tests for women of child bearing potential

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Visit 1

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  • Update on progress, physical examination
  • Food diaries are collected
  • Quality of life questionnaire 
  • Blood, urine, stool samples
  • Subjects are randomised to receive medication + dietary/exercise advice or dietary/exercise advice alone
  • Medication is given (to those in the semaglutide group)
  • Activity monitor data is uploaded
  • Pregnancy tests for women of child bearing potential
  • DXA scan (to assess body composition and bone density)
  • Fibroscan (to assess liver stiffness)
  • ECG (to assess heart function)

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Visit 2

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  • Update on progress, physical examination
  • Blood samples
  • Medication is given (to those in the semaglutide group)
  • Pregnancy tests for women of child bearing potential
  • ECG (to assess heart function)

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Visit 3

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  • Update on progress, physical examination
  • Blood, urine samples
  • Medication is given (to those in the semaglutide group)
  • Pregnancy tests for women of child bearing potential

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Visit 4

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  • Update on progress, physical examination
  • New food diaries started
  • Blood, urine samples
  • Medication is given (to those in the semaglutide group)
  • Activity monitor data is uploaded
  • Pregnancy tests for women of child bearing potential

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Visit 5

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  • Update on progress, physical examination
  • Food diaries are collected
  • Quality of life questionnaire
  • Blood, urine, stool samples
  • Activity monitors and all unused medication are collected
  • Pregnancy tests for women of child bearing potential
  • DXA scan (to assess body composition and bone density)
  • Fibroscan (to assess liver stiffness)

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Follow-up Visit

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  • Update on progress, physical examination
  • Blood, urine, stool samples

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